Analysis of concentrations of plasma HMGB1 (A), sRAGE (B), fibrinogen (C), serum hsCRP (D) between acute exacerbation and convalescence of COPD (n=44). Values of HMGB1, sRAGE, fibrinogen are expressed as mean + SD and values of hsCRP are expressed as medians (interquartile range). HMGB1, high mobility group protein B1; sRAGE, soluble receptor for advanced glycation end products; hsCRP, high-sensitivity C-reactive protein; COPD, chronic obstructive pulmonary disease; *, P<0.05; #, P<0.01; SD, standard deviation.