Table 1.
Characteristics of participants by quartiles of KIM-1 standardized to urine creatinine
| Characteristics | KIM-1 Standardized to Urine Creatinine (ng/mg) | P Value for Linear Trend | All | |||
|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |||
| Range | 29–497 | 498–814 | 815–1239 | 1240–71,535 | ||
| N | 751 | 756 | 750 | 753 | 3010 | |
| Age (yr) | 73.4 (2.8) | 73.4 (2.9) | 73.8 (2.9) | 73.8 (2.9) | <0.001 | 73.6 (2.9) |
| Men | 418 (56) | 357 (47) | 331 (44) | 361 (48) | 0.001 | 1467 (49) |
| Race/Ethnicity | ||||||
| White | 286 (38) | 356 (47) | 520 (69) | 602 (80) | <0.001 | 1764 (59) |
| Black | 465 (62) | 400 (53) | 230 (31) | 151 (20) | 1246 (41) | |
| Site | ||||||
| Memphis | 359 (48) | 353 (47) | 383 (51) | 409 (54) | 0.003 | 1504 (50) |
| Pittsburgh | 392 (52) | 403 (53) | 367 (49) | 344 (46) | 1506 (50) | |
| Education | ||||||
| Less than high school | 251 (34) | 209 (28) | 156 (21) | 140 (19) | <0.001 | 756 (25) |
| High school graduate | 214 (29) | 244 (32) | 261 (35) | 260 (35) | 979 (33) | |
| Postsecondary school | 284 (38) | 300 (40) | 332 (44) | 351 (47) | 1267 (42) | |
| Diabetes | 151 (22) | 181 (25) | 154 (21) | 212 (29) | 0.01 | 701 (24) |
| Hypertension | 517 (69) | 482 (64) | 477 (64) | 516 (69) | 0.89 | 1992 (66) |
| SBP (mmHg) | 136 (21) | 135 (21) | 136 (20) | 136 (22) | 0.66 | 136 (21) |
| Smoking | ||||||
| Never | 341 (46) | 339 (45) | 339 (45) | 291 (39) | 0.06 | 1310 (44) |
| Former | 72 (10) | 68 (9) | 75 (10) | 95 (13) | 310 (10) | |
| Current | 337 (45) | 348 (46) | 336 (45) | 364 (49) | 1385 (46) | |
| Prevalent heart failure | 22 (3) | 22 (3) | 21 (3) | 28 (4) | 0.41 | 93 (3) |
| Prevalent CHD | 143 (19) | 162 (22) | 147 (20) | 191 (26) | 0.01 | 643 (22) |
| CRP | 1.63 [0.97, 2.97] | 1.69 [1.01, 3.17] | 1.62 [0.99, 2.92] | 1.79 [1.01, 3.48] | 0.03 | 1.68 [0.99, 3.13] |
| Albumin (g/dl) | 4.02 (0.32) | 3.98 (0.31) | 3.96 (0.30) | 3.96 (0.33) | <0.001 | 3.98 (0.31) |
| LDL (mg/dl) | 122 (33) | 123 (35) | 122 (34) | 119 (37) | 0.03 | 122 (35) |
| HDL (mg/dl) | 54 (17) | 55 (18) | 54 (17) | 53 (17) | 0.04 | 54 (17) |
| eGFRcys (ml/min per 1.73 m2) | 80 (20) | 80 (20) | 80 (21) | 75 (23) | <0.001 | 79 (21) |
| eGFRcys<60 | 108 (14) | 104 (14) | 112 (15) | 185 (25) | <0.001 | 509 (17) |
| UACR (mg/g) | 6.88 [3.78, 16.92] | 7.45 [4.37, 16.61] | 8.30 [4.74, 18.03] | 11.38 [5.78, 33.41] | <0.001 | 8.26 [4.55, 20.31] |
| UACR>30 | 117 (16) | 118 (16) | 121 (16) | 202 (27) | <0.001 | 558 (19) |
Data are presented as mean (SD), n (%), or median [interquartile range].