Table 1.

Patient characteristics

Clinical Parameter	Healthy Volunteers (n=15)	Patients with Stable Allograft Function (n=41)	Patients with GD-NR (n=22)	Patients with GD-R (n=25)	P Value
Age, yr (95% CI)	45 (41 to 49)	49 (44 to 53)	51 (45 to 58)	49 (43 to 55)	NS
Men	61	66	64	64	NS
White ethnicity	68	91	92	95	0.03a
Primary renal diagnosis					NS
GN	N/A	15	45	28	0.01b
Hypertension/diabetes	N/A	15	9	4
Inherited	N/A	15	14	16
Othersc	N/A	55	32	52
Transplantation details
Graft number	N/A	1.06 (1 to 1.15)	1.26 (1.04 to 1.48)	1.1 (0.95 to 1.26)	NS
Type of allograft donor					NS
Donation after circulatory death	N/A	12	14	12
Donation after brain death	N/A	68	68	64
Live donor	N/A	20	18	24
Donor cause of death					NS
Trauma	N/A	15	29	20
Vascular	N/A	77	47	53
Other	N/A	8	24	27
HLA mismatches	N/A	2.6 (2.1 to 3.1)	1.6 (1.0 to 2.3)	2.9 (2.5 to 3.5)	0.02d
Donor age, yr (95% CI)	N/A	39 (33 to 45)	47 (38 to 55)	42 (35 to 49)	NS

Data are presented as percentages or medians (interquartile ranges) unless otherwise indicated. All categorical variables were compared using the chi-squared test. All continuous variables are analyzed using ANOVA with Tukey post hoc test for multiple comparisons if normally distributed and the Kruskal–Wallis test for variables with skewed distribution. Adjusted P values for multiple comparisons after the post hoc tests are presented. P<0.05 is significant. N/A, not applicable.

^aSignificant differences between healthy volunteers and the rest of the study population.

^bSignificant difference between patients with stable allograft function and the GD-NR group.

^cOthers include obstruction, chronic pyelonephritis, and unknown causes.

^dSignificant difference between GD-NR and other groups (stable allograft function versus GD-NR, P=0.02; GD-NR versus GD-R, P=0.01).