Table 1.
Clinical Parameter | Healthy Volunteers (n=15) | Patients with Stable Allograft Function (n=41) | Patients with GD-NR (n=22) | Patients with GD-R (n=25) | P Value |
---|---|---|---|---|---|
Age, yr (95% CI) | 45 (41 to 49) | 49 (44 to 53) | 51 (45 to 58) | 49 (43 to 55) | NS |
Men | 61 | 66 | 64 | 64 | NS |
White ethnicity | 68 | 91 | 92 | 95 | 0.03a |
Primary renal diagnosis | NS | ||||
GN | N/A | 15 | 45 | 28 | 0.01b |
Hypertension/diabetes | N/A | 15 | 9 | 4 | |
Inherited | N/A | 15 | 14 | 16 | |
Othersc | N/A | 55 | 32 | 52 | |
Transplantation details | |||||
Graft number | N/A | 1.06 (1 to 1.15) | 1.26 (1.04 to 1.48) | 1.1 (0.95 to 1.26) | NS |
Type of allograft donor | NS | ||||
Donation after circulatory death | N/A | 12 | 14 | 12 | |
Donation after brain death | N/A | 68 | 68 | 64 | |
Live donor | N/A | 20 | 18 | 24 | |
Donor cause of death | NS | ||||
Trauma | N/A | 15 | 29 | 20 | |
Vascular | N/A | 77 | 47 | 53 | |
Other | N/A | 8 | 24 | 27 | |
HLA mismatches | N/A | 2.6 (2.1 to 3.1) | 1.6 (1.0 to 2.3) | 2.9 (2.5 to 3.5) | 0.02d |
Donor age, yr (95% CI) | N/A | 39 (33 to 45) | 47 (38 to 55) | 42 (35 to 49) | NS |
Data are presented as percentages or medians (interquartile ranges) unless otherwise indicated. All categorical variables were compared using the chi-squared test. All continuous variables are analyzed using ANOVA with Tukey post hoc test for multiple comparisons if normally distributed and the Kruskal–Wallis test for variables with skewed distribution. Adjusted P values for multiple comparisons after the post hoc tests are presented. P<0.05 is significant. N/A, not applicable.
Significant differences between healthy volunteers and the rest of the study population.
Significant difference between patients with stable allograft function and the GD-NR group.
Others include obstruction, chronic pyelonephritis, and unknown causes.
Significant difference between GD-NR and other groups (stable allograft function versus GD-NR, P=0.02; GD-NR versus GD-R, P=0.01).