Table 2.
Characteristics of study participants based on the occurrence of class I and II adverse safety events
| Demographic Variable | Eventsa | Class I and Class II Events | Class I but No Class II Events | Class II but No Class I Events | Total |
|---|---|---|---|---|---|
| All participants, n (row %) | 82 (30.7) | 48 (18.0) | 106 (39.7) | 31 (11.6) | 267 (100.0) |
| Age | |||||
| Mean±SD (yr) | 65.7±12.6 | 65.7±12.6 | 65.7±12.6 | 65.7±12.6 | 65.7±12.6 |
| <65 yr, n (%) | 32 (39.0) | 23 (47.9) | 48 (45.3) | 15 (48.4) | 118 (44.2) |
| ≥65 yr, n (%) | 50 (61.0) | 25 (52.1) | 58 (54.7) | 16 (51.6) | 149 (55.8) |
| Sex, n (%) | |||||
| Female | 21 (25.6) | 18 (37.5) | 26 (24.5) | 10 (32.3) | 75 (28.1) |
| Male | 61 (74.4) | 30 (62.5) | 80 (75.5) | 21 (67.7) | 192 (71.9) |
| African American, n (%) | |||||
| No | 23 (28.1) | 17 (35.4) | 35 (33.0) | 10 (32.3) | 85 (31.8) |
| Yes | 59 (72.0) | 31 (64.6) | 71 (67.0) | 21 (67.7) | 182 (68.2) |
| Diabetes, n (%) | |||||
| No | 49 (59.8) | 10 (20.8) | 28 (26.4) | 11 (35.5) | 98 (36.7) |
| Yes | 33 (40.2) | 38 (79.2) | 78 (73.6) | 20 (64.5) | 169 (63.3) |
| Cancer, n (%) | |||||
| No | 69 (84.1) | 38 (79.2) | 81 (76.4) | 25 (80.7) | 213 (79.8) |
| Yes | 13 (15.9) | 10 (20.8) | 25 (23.6) | 6 (19.3) | 54 (20.2) |
| Cardiovascular disease, n (%) | |||||
| No | 54 (65.9) | 17 (35.4) | 35 (33.0) | 10 (32.3) | 116 (43.4) |
| Yes | 28 (34.1) | 31 (64.6) | 71 (67.0) | 21 (67.7) | 151 (56.6) |
| GFR | |||||
| Mean±SD (ml/min per 1.73 m2) | 44.4±12.0 | 36.6±13.8 | 42.1±15.6 | 43.1±13.6 | 41.9±14.2 |
| ≥45 ml/min per 1.73 m2, n (%) | 38 (46.3) | 14 (29.2) | 46 (43.4) | 14 (45.2) | 112 (42.0) |
| <45 ml/min per 1.73 m2, n (%) | 44 (53.7) | 34 (70.8) | 60 (56.6) | 17 (54.8) | 155 (58.0) |
| Annual household income, n (%) | |||||
| ≤$50,000b | 58 (70.7) | 36 (75.0) | 75 (70.8) | 26 (83.9) | 195 (73.0) |
| >$50,000 | 24 (29.3) | 12 (25.0) | 31 (29.2) | 5 (16.1) | 72 (27.0) |
| Education, n (%) | |||||
| No high school diploma | 43 (52.44) | 32 (66.67) | 48 (45.28) | 14 (45.16) | 137 (51.31) |
| High school or greater | 39 (47.56) | 16 (33.33) | 58 (54.72) | 17 (54.84) | 130 (48.69) |
| Currently married, n (%) | |||||
| No | 56 (68.29) | 25 (52.08) | 54 (50.94) | 21 (67.74) | 156 (58.43) |
| Yes | 26 (31.71) | 23 (47.92) | 52 (49.06) | 10 (32.26) | 111 (41.57) |
| Hypertension, n (%) | |||||
| No | 3 (3.66) | 1 (2.08) | 6 (5.66) | 0 (0.00) | 10 (3.75) |
| Yes | 79 (96.34) | 47 (97.92) | 100 (94.34) | 31 (100.00) | 257 (96.25) |
| Median medications (interquartile range) (n)c | |||||
| 10 (7–14) | 14 (12–17) | 14 (11–19) | 11 (9–15) | 13 (9–17) |
All percentages are column percentages unless otherwise indicated.
a
All detected events are conditional on use of a drug from a class listed in Table 1.
b
Includes participants who declined to answer.
c
Number of medication components.