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NAQ antinociception antagonism study in the tail-flick assay. (A) NAQ was pretreated as indicated for 10, 30 and 60 minutes, and followed by 18 mg/kg morphine. Maximal NAQ antagonism was seen at 10 and 30 minutes, and absent by 60 minutes.; (B) Using a 10 minute NAQ pretreatment time, an antagonist dose-response curve was generated using NAQ.
