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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Nat Commun. 2014;5:3127. doi: 10.1038/ncomms4127

Figure 7. The proposed model depicting a role for EED in orchestrating PRC2 and PRC1 function in epigenetic regulation.

Figure 7

EED is critical for PRC2 to methylate histone H3 at lysine 27. Once H3K27 are methylated, EED directly recruits PRC1 to the tri-methylated H3K27 loci and enhances PRC1 ubiquitin E3 ligase activity.