Table 3.
The relationship between genotype combinations with blood pressures, anthropometric variables, and plasma leptin levels
| Variable |
Mean ± SD |
|
|
|---|---|---|---|
|
Subjects homozygous for all four SNPs
a
|
Subjects not homozygous for all four SNPs |
P | |
| (n = 70) | (n = 338) | ||
| SBP (mmHg) |
137.40 ± 19.83 |
139.83 ± 22.23 |
0.398 |
| DBP (mmHg) |
81.55 ± 10.51 |
80.98 ± 10.78 |
0.688 |
| Pulse rate (bpm) |
74.48 ± 12.60 |
73.98 ± 13.10 |
0.768 |
| WC (cm) |
90.94 ± 12.50 |
91.01 ± 11.51 |
0.966 |
| HC (cm) |
101.20 ± 11.09 |
102.13 ± 9.91 |
0.484 |
| WHR |
0.90 ± 0.08 |
0.89 ± 0.08 |
0.457 |
| Height (cm) |
161.11 ± 8.54 |
159.81 ± 9.39 |
0.283 |
| Weight (kg) |
70.38 ± 16.34 |
69.59 ± 14.63 |
0.686 |
| BMI (kg/m2) |
27.04 ± 5.57 |
27.20 ± 5.00 |
0.813 |
| TBFb (%) |
31.92 ± 6.53 |
33.59 ± 6.98 |
0.131 |
| SFb (%) |
25.25 ± 7.84 |
27.60 ± 8.20 |
0.045 |
| VFLb (%) |
12.64 ± 6.87 |
12.19 ± 6.23 |
0.672 |
| RM (kcal) |
1,491.96 ± 282.82 |
1,448.95 ± 258.76 |
0.214 |
| SMb (%) |
25.78 ± 3.82 |
24.91 ± 4.08 |
0.084 |
| Leptinb (ng/mL) | 21.22 ± 27.96 | 30.50 ± 37.77 | 0.015 |
All values by Student’s t-test, significant at P < 0.05 and indicated in bold font.
aSubjects with homozygous mutated genotypes for all four SNPs: GG for LEP A19G, AA for LEP G2548A, RR for both LEPR K109R and LEPR Q223R.
bValues were log transformed before analysis.