Fig. 1.

AMH induces migration of mesonephric cells into XX gonads. Gonads from 11.5 dpc CD-1 embryos were cultured with mesonephroi from 11.5 dpc ROSA26 mice for 48 h and stained for lacZ activity. (A) XX gonads cultured with a ROSA26 mesonephros did not contain any lacZ-positive blue cells. (B) In contrast, numerous cells migrated into an XY gonad. (C) Migration was also observed in XX gonads cultured with a ROSA26 mesonephros in the presence of 15 μg/ml recombinant human AMH protein.