Skip to main content
. Author manuscript; available in PMC: 2015 May 9.
Published in final edited form as: Circ Res. 2014 May 9;114(10):1554–1557. doi: 10.1161/CIRCRESAHA.114.303960

Figure 1.

Figure 1

Mechanisms of nitrite-mediated cytoprotection. In the cardiomyocytes nitrite is reduced to NO by reactions with deoxy-myoglobin and then can react with and inhibit complex I of the mitochondrial electron transport chain. This inhibition is reversible and occurs immediately during reperfusion to limit reactive oxygen species formation and to prevent the release of cytochrome c. Figure adapted from Bueno et al, “Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics.” Antioxidants & redox signaling, 2013. 18(14): p. 1797-809.