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. 2014 Jun 27;6:140. doi: 10.3389/fnagi.2014.00140

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Copyright © 2014 Sleimen-Malkoun, Temprado and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aging as a macro dynamic phenomenon on an epigenetic landscape (inspired by Waddington, 1942). A metaphoric representation of the life-span evolution of the landscape of behavioral attractors. During development, the number of attractor stable states (represented by wells in which a rolling ball can be trapped) increases through a differentiation process (filled lines arrows). Conversely, during aging (dashed lines arrows), the landscape goes through a dedifferentiation process leading to the disappearance or merging of some attractors.