Table 1.

BRCA1/ER/PR/HER2 Status of Breast Cancer Cell Lines

	ER	PR	HER2/neu†	BRCA1 Mutation Status	BRCA1*	gamma-tubulin level/cell‡	% soluble gamma-tubulin
MCF-10A	−	−	−	WT	NA	++	51.9
BT-20	−	−	+	WT	+	+	56.1
SKBR3	−	−	++	WT	++	+	62.8
BT-549	−	−	−	WT	++	+++	70.9
MCF-7	+	+	+/−	WT	+/−	+	55.1
BT-474	+	+	++	WT	++	+	73.8
MDA-MB-436	−	−	−	5396 + 1G > A	++**	++	63.4
Hs578T	−	−	+/−	WT	++	+++	78.9
MDA-MB-231	−	−	+/−	WT	++	+++	68.4
HCC1428	+	+	−	NA	−	+	70.3
HCC1937	−	−	−	5382insC	++	++++	70.9

^*++ normal transcript levels, + low transcript levels, +/− barely detectable levels

^**different length transcripts

NA data not available

^†− negative, +/− low, + normal, ++ overexpression

^‡+ low, ++ medium, +++ high, ++++ very high