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. 2014 Feb 7;210(2):306–310. doi: 10.1093/infdis/jiu087

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Superoxide dismutase 1 (SOD1) correlates to parasite burden in vitro and in situ in diffuse cutaneous leishmaniasis (DCL). A and B, Human macrophages were infected with Leishmania amazonensis (5:1 ratio) for 4 hours and then treated in the absence or presence of SOD1 protein (175 U/mL) for 48 hours. Cells were fixed on glass slides and stained with hematoxylin and eosin. A, Parasite burden was quantified; each bar represents the mean ± standard error of the mean for 3 donors (*P = .042, by the t test). B, Infected macrophages (1000× magnification) left untreated (left panel) or treated with SOD1 (right panel). C, Cutaneous lesion biopsy specimen from a representative patient with DCL stained with hematoxylin and eosin (1000× magnification). D, Positive correlation between human SOD1 and parasite SOD2 (r = 0.98, P = .019) and SOD4 (r = 0.99, P = .0026) messenger RNA (mRNA) levels (normalized to G6PD), quantified by nCounter in situ in biopsy specimens from patients with DCL (n = 4).