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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: Faraday Discuss. 2011;148:443–448. doi: 10.1039/c005523a

Fig. 5.

Fig. 5

Complexity derived from Mullerian and Darwinian sources in natural protein and in simple proteins engineered from scratch (maquettes). The figure explains that any amino acid serves a number of utilities in a protein. It also demonstrates that an amino acid or a function in a protein displays interdependencies, close and far, with a number of other amino acids. The maquette approach to protein construction diminishes both the number of utilities and interdependencies.