Table 3. Global changes in histone methylation marks have been reported in various types of cancers.

Correlative studies report altered histone methylation patterns in specific cancer types^189–197. In some of these cases multiple methyl marks have been shown to change in concert highlighting the importance of combinatorial modifications effect on biological functions.

Cancer type	Methyl mark	Consequence	Reference
Prostate cancer	↓ H3K4me2	Higher recurrence	1
	↓ H4R2me2	Higher recurrence	1
Lung cancer	↓ H3K4me2	Poorer survival	2, 3
Kidney cancer	↓ H3K4me2	Poorer survival	3
Breast cancer	↓ H3K4me2	Poorer survival	5
	↓ H3K27me3	Poorer survival	7
	↓ H4R3me2	Worse clinical outcomes	5
	↓ H4K20me3	Worse clinical outcomes	5
Pancreatic cancer	↓ H3K4me2	Poorer survival	4
	↓ H3K9me2	Poorer survival	4
	↓ H3K27me3	Poorer survival	7
Gastric adenocarcinoma	↑ H3K9me3	Poorer survival	6
Ovarian cancer	↓ H3K27me3	Poorer survival	7
Lymphomas	↓ H4K20me3	Associated with	8
Colon adenocarcinomas	↓ H4K20me3	Associated with	8