Table 4.
Treatment effects
| Group | Baseline Value | 0–12 mo Change | Main Effect of T | Main Effect of F | Interaction |
|---|---|---|---|---|---|
| Vehicle-Placebo | 13.4 (12.8 to 14.2) [16] | 0.00 (−0.44 to 4.4) [12] | 1.13 (0.68 to 1.56) | 0.28 (0.07 to 0.49) | 0.31 (−0.15 to 1.14) |
| Vehicle-Finasteride | 13.8 (12.9 to 14.7) [13] | −0.28 (−0.95 to 0.40) [8] | P < 0.001 | P = 0.18 | P = 0.46 |
| TE-Placebo | 14.7 (13.9 to 15.5) [13] | 1.06 (−0.31 to 2.43) [5] | |||
| TE-Finasteride | 14.6 (14.1 to 15.1) [17] | 1.31 (0.45 to 2.16) [11] | |||
| Vehicle-Placebo | 2.30 (0.91 to 3.6) [16] | 0.062 (−0.12 to 0.24) [12] | 0.54 (0.34 to 0.75) | 0.12 (−0.08 to 0.32) | −0.10 (−0.50 to 0.30) |
| Vehicle-Finasteride | 2.45 (1.2 to 3.7) [13] | −0.030 (−0.56 to 0.50) [6] | P < 0.001 | P = 0.24 | 0.62 |
| TE-Placebo | 2.76 (1.2 to 4.3) [13] | 0.055 (−0.67 to 0.78) [6] | |||
| TE-Finasteride | 2.86 (1.2 to 4.5) [17] | 0.30 (−0.18 to 0.78) [10] | |||
| Vehicle-Placebo | 1.33 (−0.022 to 2.6) [16] | 0.056 (−0.19 to 0.30) [12] | 0.77 (0.51 to 1.03) | 0.034 (−0.22 to 0.29) | −0.17 (−0.67 to 0.33) |
| Vehicle-Finasteride | 1.39 (−0.040 to 2.8) [13] | −0.057 (−0.80 to 0.69) [6] | P < 0.001 | P = 0.79 | P = 0.51 |
| TE-Placebo | 1.75 (−0.21 to 3.7) [13] | 0.18 (−0.58 to 0.94) [6] | |||
| TE-Finasteride | 1.88 (0.018 to 3.7) [17] | 0.45 (−0.078 to 0.97) [10] | |||
| Vehicle-Placebo | 160.2 (145.2 to 175.3) [16] | 0.17 (−13.2 to 13.5) [12] | −0.81 (−12.0 to 10.4) | −4.9 (−16.1 to 6.30) | −20.5 (−42.9 to 1.89) |
| Vehicle-Finasteride | 160.5 (143.9 to 177.2) [13] | −9.25 (−35.0 to 16.5) [8] | P = 0.88 | P = 0.40 | P = 0.074 |
| TE-Placebo | 161.2 (140.0 to 182.2) [13] | 17.5 (−25.5 to 60.2) [6] | |||
| TE-Finasteride | 173.6 (149.3 to 198.0) [17] | −4.46 (−18.6 to 9.65) [11] | |||
| Vehicle-Placebo | 89.8 (75.2 to 104.3) [16] | −2.58 (−14.3 to 9.14) [12] | 10.5 (0.54 to 20.4) | −11.5 (−18.9 to −1.5) | −21.7 (−41.6 to −1.87) |
| Vehicle-Finasteride | 85.8 (72.6 to 99.0) [13] | −20.9 (−44.1 to 2.36) [8] | P = 0.041 | P = 0.026 | P = 0.037 |
| TE-Placebo | 84.5 (64.4 to 104.5) [13] | 25.3 (−22.2 to 72.8) [6] | |||
| TE-Finasteride | 94.1 (75.1 to 113.0) [17] | −0.82 (−9.87 to 8.23) [11] | |||
| Vehicle-Placebo | 144.0 (111.1 to 176.9) [16] | 4.33 (−18.7 to 27.4) [12] | −42.8 (−71.2 to −14.3) | 42.6 (14.1 to 71.0) | −17.1 (−74.0 to 39.9) |
| Vehicle-Finasteride | 148.1 (114.2 to 182.0) [13] | 46.4 (−7.4 to 100.1) [8] | P = 0.0051 | P = 0.0046 | P = 0.55 |
| TE-Placebo | 154.6 (100.8 to 208.4) [13] | −16.5 (−39.2 to 6.22) [6] | |||
| TE-Finasteride | 183.4 (135.1 to 231.8) [17] | −2.72 (−58.7 to 53.2) [11] | |||
| Vehicle-Placebo | 1.10 (0.97 to 1.26) [16] | −0.01 (−0.59 to 0.04) [12] | 0.072 (0.018 to 0.13) | 0.019 (−0.031 to 0.068) | −0.11 (−0.15 to 0.022) |
| Vehicle-Finasteride | 1.08 (0.84 to 1.32) [13] | 0.10 (−0.01 to 0.21) [8] | P = 0.010 | P = 0.45 | P = 0.034 |
| TE-Placebo | 0.97 (0.89 to 1.04) [13] | 0.083 (0.004 to 0.16) [6] | |||
| TE-Finasteride | 0.88 (0.77 to 1.01) [17] | 0.091 (0.004 to 0.18) [11] | |||
| Vehicle-Placebo | 24.9 (21.1 to 28.7) [16] | −0.50 (−4.62 to 3.62) [12] | 1.19 (−2.59 to 4.93) | 1.89 (−1.88 to 5.66) | −1.02 (−8.56 to 6.52) |
| Vehicle-Finasteride | 23.6 (17.1 to 30.1) [13] | 2.13 (−2.35 to 6.60) [8] | P = 0.53 | P = 0.32 | P = 0.78 |
| TE-Placebo | 24.9 (19.9 to 29.9) [13] | 1.33 (−1.53 to 4.20) [6] | |||
| TE-Finasteride | 46.8 (16.3 to 77.2) [17] | −9.82 (−28.2 to 8.56) [11] | |||
| Vehicle-Placebo | 21.9 (18.3 to 25.4) [16] | −0.67 (−4.55 to 3.22) [12] | 0.075 (−5.31 to 5.46) | 4.16 (−1.23 to 9.54) | 1.72 (−9.02 to 12.5) |
| Vehicle-Finasteride | 21.8 (15.6 to 28.1) [13] | 1.75 (−3.28 to 6.78) [8] | P = 0.98 | P = 0.13 | P = 0.75 |
| TE-Placebo | 23.3 (19.1 to 27.5) [13] | −2.67 (−8.40 to 3.07) [6] | |||
| TE-Finasteride | 58.0 (17.7 to 98.3) [17] | −11.2 (−35.8 to 13.4) [11] | |||
| Vehicle-Placebo | 67.1 (54.6 to 79.7) [16] | 3.33 (−1.38 to 8.05) [12] | −6.88 (−11.5 to 2.28) | 2.76 (−1.94 to 7.46) | 3.43 (−6.07 to 12.9) |
| Vehicle-Finasteride | 89.5 (63.5 to 115.6) [13] | 1.00 (−10.7 to 8.68) [8] | P = 0.0044 | P = 0.24 | P = 0.47 |
| TE-Placebo | 79.4 (62.4 to 96.3) [13] | −8.50 (−22.5 to 5.47) [6] | |||
| TE-Finasteride | 72.1 (60.2 to 83.9) [17] | −6.46 (−14.0 to 1.06) [11] |