. 2010 Jan 26;41(2):161–170. doi: 10.1152/physiolgenomics.00197.2009

Table 3.

Canonical pathways of genes most affected by energy balance (negative vs. positive) in mammary quarters during intramammary challenge with S. uberis using IPA

	#Genes/Total^§		Genes
Canonical Pathway	Upregulated	Downregulated	Upregulated	Downregulated
IL-8 signaling	2/183	8/183	GNG12, HMOX1^^§*	AKT1^, CCND1, GNG3, IRAK1^, MAPK9^, RHOU, SRC, TRAF6^
Glucocorticoid receptor signaling	3/275	10/275	ANXA1^, HSPA2, DUSP1*	AKT1^, CCL5, CSN2^, GTF2F2, JAK1^, MAPK9^, POLR2E, TAF6L, TGFBR2, TRAF6^*
NRF2-mediated oxidative stress response	4/181	6/181	ACTG1, DNAJB2, HMOX1^, JUND*	AKT1^, CDC34, GSTA4, GSTM3, MAPK9^

^§

# Genes/Total, number of differentially expressed genes from microarray (FDR P ≤ 0.06; P < 0.01) and qPCR analysis (P ≤ 0.05) out of total #of genes associated with the canonical pathway according to IPA.

qPCR expression results for verification of genes differentially expressed on microarray as well as genes selected for qPCR analysis not present on microarray.