. 2010 Jan 26;41(2):161–170. doi: 10.1152/physiolgenomics.00197.2009

Table 4.

Functions of genes most affected by energy balance (negative vs. positive) in mammary quarters during intramammary challenge with S. uberis using IPA (FDR P ≤ 0.06; P ≤ 0.01)

	Genes
Function^§	Upregulated	Downregulated
Cell Growth and Proliferation (48)
Growth of cells	ACTG1, ACTN4, ANXA1^^§, ACPDD1, ARHGEF1, DNAJB2, ELGN2, HMOX1^, HSPB2, INSR^, LEF1, USP21*	ADFP, ADRA1A, AKT1^, CCNA2, CCND1, COX17, DAP, ELF1, EPHA2, FXYD1, HK1, MAPK9^, MMP15, NOTCH1, PLEC1, SOCS2, SPARC^, SPINT2, SRC, SREBF1, TGFBR2, UBA1, UBE2B, USP9X*
Proliferation of cell lines	ANXA1^, FSCN1, HMOX1^, INSR^, LEF1*	ADRA1A, AKT1^, APP, CCNA2, CCND1, EPHA2, HK1, JAK1^, MAPK9^, NOTCH1, PPAP2C, PTPRF, SOCS2^, SPARC^, SRC, STARD13, TGFBR2*
Cellular Development (36)
Development of cells	ARHGEF1, CTNNA1, GNG12, INSR^, LEF1, RSP19*	AKT1^, ANPEP, CCL5, CCND1, EPHA2, HSF1, IRAK1^* MAPK9^, MYF5, NFYA, NOTCH1, RAPGEF1, RHOU, SPARC^, SRC, TGFBR2, TRAF6^, UBE2B
Development of breast cell lines		AKT1,CCND1,EPHA2,NOTCH1,SRC, UBE2B

^§

Within Cell Growth and Proliferation, a total of 14 genes were upregulated and 24 genes were downregulated. Within Cellular Development, a total of 9 genes were upregulated and 27 genes were downregulated.

qPCR expression results for verification of genes differentially expressed on microarray as well as genes selected for qPCR analysis not present on microarray.