Fig. 3.
Effect of calphostin C, Gö-6850 (Gö), and Y-27632 (10−8–10−4 M) on slow-rate phasic activity in RSM. A: absolute change in rate of contraction (Cont) with different inhibitors. B: percent maximal decrease. Inset: RSM force recording. Dashed lines in the inset represent cutoff filters for the high- and low-amplitude phasic activities. C and D: corresponding changes in amplitudes (Amp) as absolute decrease and percent maximal decrease in slow-rate phasic activity in RSM. Data show significant decrease in rate, as well as amplitude, following PKC inhibitors (calphostin C and Gö-6850, *P < 0.05, n = 5) and even further significantly higher with the ROCK inhibitor Y-27632 (**P < 0.01, n = 5).