Table 1.

Effect of glyburide on CP-induced urodynamic parameters

Experimental Group	Voiding Pressure, cmH2O	Threshold Pressure, cmH2O	Void Volume, ml	Intercontraction Interval, s	Number of Nonvoiding Contractions per Cystometrogram
Vehicle	59.7 ± 3.5	18.5 ± 2.2	0.90 ± 0.08	679 ± 50	1.61 ± 0.41
Cyclophosphamide	68.7 ± 3.9*	19.8 ± 2.4	0.68 ± 0.09*	506 ± 56*	1.46 ± 0.64
Glyburide	64.3 ± 4.5	21.8 ± 2.7	1.28 ± 0.10*	862 ± 66*	2.33 ± 0.88
Glyburide + cyclophosphamide	74.7 ± 4.1*	21.0 ± 2.5	1.21 ± 0.09*	897 ± 60*	2.28 ± 0.68

Values are means ± SE; n = 18 for vehicle, 7 for cyclophosphamide, 4 for glyburide, and 7 for glyburide + cyclophosphamide treatment. Rats with suprapubic catheters implanted were subjected to the treatment regimen shown in Fig. 3. At the end of the experiment, urodynamics were performed as described in materials and methods. For each rat in each group, three to eight filling-voiding cycles were analyzed. Each parameter was quantitated for each cycle, and the mean was determined. The mean of each parameter from each rat was averaged with the means from the other rats in the group, and this (the mean of the means) is shown here.

^*Significant differences from control as assessed with a general linear mixed model (P < 0.05).