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. 2013 Jun 5;110(5):1097–1106. doi: 10.1152/jn.00114.2013

Fig. 6.

Fig. 6.

VIP-induced increase spike frequency was mediated by fast delayed rectifier (FDR) current. A: average firing rate for each group (+SE). *Significant difference (P < 0.05) analyzed by 1-way ANOVA followed by Dunn's method for multiple comparisons (vs. VIP). For each, VIP was applied at 1 μM and 4-aminopyridine (4-AP) at 0.5 mM. For each group, n = 30. B: representative examples showing that application of VIP (1 μM) increases the magnitude of FDR currents in dSCN. C: current (I)-voltage (V) relationship of FDR currents in SCN neurons. Data are shown as means ± SE. *Significant difference (P < 0.05) analyzed by 2-way repeated-measures ANOVA followed by Holm-Sidak method for multiple comparisons (vs. control). For each group, n = 11 or 12. FDR currents were isolated by subtraction (baseline, 0.5 mM 4-AP) using a voltage-step protocol with a prepulse potential of −90 mV and test pulse potentials (see materials and methods). Holding potential was −70 mV.