Fig. 8.
Effects of long-term NH125 treatment on blood pressure (BP; A), heart rate (HR; B), and body weight (BW; C) of spontaneously hypertensive rats (SHR). NH125 was administered to SHR (4 wk old) or age-matched Wistar Kyoto rats (WKY) subcutaneously at a dose of 500 μg·kg−1·day−1 for 6 wk (n = 6). Systolic BP (SBP) and HR (in beats/min) of SHR and WKY were measured using a tail-cuff system at weekly intervals. Results were expressed as means ± SE. *P < 0.05, **P < 0.01 vs. WKY; #P < 0.05, ##P < 0.01 vs. SHR.