Table 6.
Summary of S1PR3 SNPs studied for association with ARDS in Chicago samples
| HWE |
Genotype Count |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Position* | SNP rs no. | Controls | Cases | Allele 1/Allele 2 | Allele 1 frequency | Ca | Co | Rsq† | OR (allele 1) | SE (OR) | P Value |
| African descent | |||||||||||
| 90794283 | rs7022797 | 0.763 | 0.218 | G/T | 0.42 | 10/16/14 | 30/93/64 | 0.91 | 0.30 | 0.676 | |
| 90794397 | rs11137480 | 0.749 | 0.114 | C/G | 0.37 | 10/14/14 | 25/83/78 | 1.07 | 0.29 | 0.369 | |
| 90794814 | rs7022664 | G/A | 0.83 | 0.71 | 0.97 | 0.47 | 0.954 | ||||
| 90796023 | rs4877039 | G/C | 0.53 | 0.85 | 1.09 | 0.31 | 0.776 | ||||
| 90797066 | rs73654718 | 1 | 1 | A/G | 0.86 | 29/10/1 | 138/46/3 | 0.76 | 0.39 | 0.947 | |
| 90797534 | rs7863572 | T/C | 0.39 | 0.85 | 1.00 | 0.32 | 0.993 | ||||
| 90797689 | rs6559331 | C/T | 0.43 | 0.79 | 0.96 | 0.33 | 0.909 | ||||
| 90797872 | rs11398943 | 0.372 | 1 | —/A | 0.44 | 6/17/13 | 33/99/54 | 0.77 | 0.33 | 0.415 | |
| 90798448 | rs10867149 | T/C | 0.31 | 0.70 | 1.13 | 0.37 | 0.742 | ||||
| 90800116 | rs73496046 | C/T | 0.87 | 0.55 | 3.75 | 0.82 | 0.108 | ||||
| 90800363 | rs3934594 | G/A | 0.65 | 0.52 | 1.14 | 0.42 | 0.756 | ||||
| 90800415 | rs11137481 | 1 | 0.463 | T/G | 0.92 | 32/8/1 | 162/24/0 | ||||
| 90800749 | rs7045576 | 0.613 | 0.33 | A/G | 0.17 | 3/11/27 | 7/52/128 | 1.55 | 0.37 | 0.240 | |
| 90801401 | rs6559333 | G/C | 0.85 | 0.32 | 0.98 | 0.66 | 0.979 | ||||
| 90802459 | rs7858626 | A/G | 0.24 | 0.76 | 1.91 | 0.35 | 0.062 | ||||
| 90802703 | rs7870888 | G/A | 0.86 | 0.71 | 1.22 | 0.50 | 0.687 | ||||
| 90802886 | rs7038457 | 1 | 0.003 | T/C | 0.70 | 28/6/5 | 91/78/16 | 1.36 | 0.33 | 0.130 | |
| 90803463 | rs58235552 | 1 | 0.336 | C/G | 0.85 | 31/6/1 | 129/50/5 | 1.32 | 0.43 | 0.214 | |
| 90804199 | rs73496049 | 1 | 0.183 | A/C | 0.94 | 35/4/1 | 164/23/0 | ||||
| 90807194 | rs73496050 | 0.201 | 1 | G/A | 0.77 | 25/13/1 | 117/58/12 | 1.23 | 0.34 | 0.780 | |
| 90807402 | rs41287349 | G/A | 0.67 | 0.80 | 1.50 | 0.35 | 0.243 | ||||
| 90807922 | rs7853537 | A/G | 0.77 | 0.81 | 1.47 | 0.42 | 0.359 | ||||
| 90807926 | rs7865415 | G/A | 0.86 | 0.67 | 2.93 | 0.71 | 0.128 | ||||
| 90809094 | rs1129925 | G/A | 0.23 | 0.87 | 1.56 | 0.34 | 0.186 | ||||
| 90809604 | rs1867 | C/T | 0.89 | 0.58 | 1.11 | 0.60 | 0.867 | ||||
| 90809944 | rs9314668 | G/A | 0.87 | 0.73 | 1.03 | 0.48 | 0.949 | ||||
| 90811017 | rs7865979 | 1 | 0.437 | A/G | 0.76 | 19/13/4 | 104/70/12 | 0.77 | 0.32 | 0.399 | |
| European descent | |||||||||||
| 90794283 | rs7022797 | 0.625 | 0.764 | G/T | 0.36 | 5/26/38 | 25/75/61 | 0.67 | 0.22 | 0.017 | |
| 90794397 | rs11137480 | 0.875 | 0.764 | C/G | 0.36 | 5/26/38 | 26/85/74 | 0.67 | 0.22 | 0.042 | |
| 90794814 | rs7022664 | G/A | 0.57 | 0.70 | 0.81 | 0.27 | 0.021 | ||||
| 90796023 | rs4877039 | C/G | 0.63 | 0.90 | 0.63 | 0.28 | 0.045 | ||||
| 90797534 | rs7863572 | C/T | 0.46 | 0.80 | 0.71 | 0.21 | 0.126 | ||||
| 90797689 | rs6559331 | T/C | 0.4 | 0.80 | 0.10 | 1.10 | 0.092 | ||||
| 90798448 | rs10867149 | C/T | 0.52 | 0.70 | 0.61 | 0.34 | 0.048 | ||||
| 90800363 | rs3934594 | A/G | 0.42 | 0.70 | 0.93 | 0.27 | 0.058 | ||||
| 90800749 | rs7045576 | 0.009 | 0.32 | G/A | 0.51 | 9/38/22 | 57/67/46 | 0.57 | 0.25 | 0.063 | |
| 90802459 | rs7858626 | A/G | 0.51 | 0.60 | 1.66 | 0.28 | 0.441 | ||||
| 90802703 | rs7870888 | 0.656 | 1 | G/A | 0.82 | 49/17/1 | 117/59/9 | 0.63 | 0.23 | 0.136 | |
| 90802886 | rs7038457 | 1 | 1 | T/C | 0.91 | 52/13/1 | 153/30/1 | 0.70 | 0.24 | 0.267 | |
| 90807922 | rs7853537 | A/G | 0.91 | 1.00 | 1.76 | 0.28 | 0.137 | ||||
| 90809094 | rs1129925 | G/A | 0.49 | 0.50 | 1.13 | 0.20 | 0.799 | ||||
| 90809604 | rs1867 | 1 | 0.641 | C/T | 0.79 | 51/17/2 | 110/66/9 | 0.67 | 0.24 | 0.096 | |
| 90809944 | rs9314668 | 0.837 | 0.637 | G/A | 0.79 | 52/17/2 | 108/69/9 | 0.61 | 0.25 | 0.069 | |
| 90811017 | rs7865979 | 0.658 | 0.802 | A/G | 0.57 | 23/31/12 | 58/89/39 | 0.61 | 0.26 | 0.581 | |
Statistically significant P values are in bold. SNP, single nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; Rsq, squared correlation between imputed and true genotypes as an estimate of the imputation quality as provided by MaCH (see Ref. 21); OR, odds ratio; SE, standard error. Tagging SNPs (tSNPs) are denoted in bold.
*
Chromosome position according to NCBI build 36. SNPs rs11137481 and rs73496049 with minor allele frequency (MAF) <10% were excluded from downstream association analysis based on the filtering criteria (MAF <10% or Rsq <0.3). Analyses were conducted for 17 SNPs in the EDs and 25 in ADs adjusting for ancestry estimated.