Fig. 2.

Exercised mice partially rescue oxidative phosphorylation (OXPHOS) function in muscle homogenates. A and B: cytochrome-c oxidase (COX) activity of exercised, sedentary COX10 KO and sedentary wild-type mice at different ages comparing muscle homogenates and muscle mitochondria (n = 3 for each group). * P < 0.01, ** P < 0.001. C: quantification of mitochondrial proteins and loading control in muscle homogenates and muscle mitochondria of 6-mo exercised (Exerc), sedentary (Sed) COX10 KO, and sedentary wild-type mice by Western blot and densitometry (n = 3 for each group). SDH, succinate dehydrogenase.