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. 2014 Jun 20;9:3013–3026. doi: 10.2147/IJN.S62260

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© 2014 Sun et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Permeability of fluorescein-labeled dextran-70,000 and IONPs across osmotically disrupted bEnd.3 cell monolayers in the presence and absence of a magnetic field. Fluorescein-labeled dextran-70,000 flux was determined in control monolayers and monolayers treated with AmS-IONPs (A) and EDT-IONPs (C). The permeability of AmS-IONPs (B) and EDT-IONPs (D) was determined at 8 and 24 hours.

Notes: Quantitative determination of IONP permeability was based on the amount of Fe in a basolateral compartment over the amount of Fe loaded in an apical compartment expressed as a percentage. Values represent the mean ± standard error of the mean of three samples per treatment group. **P<0.01 compared with the same treatment group but without magnetic field.

Abbreviations: AmS-IONPs, aminosilane-coated iron oxide nanoparticles; EDT-IONPs, N-(trimethoxysilylpropyl)ethylenediaminetriacetate-coated iron oxide nanoparticles; IONPs, iron oxide nanoparticles.