Table 1.

Metabolic parameters in WT vs. MKO mice at different ages

	3 Mo		12 Mo		24 Mo
	WT	KO	WT	KO	WT	KO
Weight, g	23.4 ± 0.9	25.7 ± 0.7	36.6 ± 1.2	39.3 ± 2.2	33.9 ± 1.1	36.4 ± 2.1
Fasting glucose, mg/dl	96.7 ± 5.7	79.3 ± 6.8*	97.6 ± 4.3	83.8 ± 2.8*	91.0 ± 6.0	76.6 ± 9.5
Insulin, ng/ml	0.49 ± 0.05	0.37 ± 0.02*			1.06 ± 0.1	0.51 ± 0.1*

Data are expressed as means ± SE (n = 9–12 mice for 3- to 12-mo-old groups, n = 5 for 24-mo-old group).

WT, wild type; MKO, muscle-specific Pgc-1α knockout.

^*P < 0.05, comparing WT and MKO of similar age.