Figure 1. Diagrammatic presentation for the course of the experiment.

DMH was administered as (20 mg/kg/week, s.c.). Metformin (100 or 200 mg/kg/day) was given orally. Oxaliplatin was administered weekly in a dose equals 4 mg/kg/week (i.p.). BD: basal diet, HFD: high-fat diet, DMH: 1,2-dimethyhydrazine. All experimental groups received DMH before starting the indicated treatments except saline groups.