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. 2014 Jun 27;9(6):e100562. doi: 10.1371/journal.pone.0100562

Table 1. Effect of the treatment oxaliplatin and/or metformin (100 or 200 mg/kg) on body weight in A) non-diabetic mice (experiment I) and B) diabetic mice (experiment II).

A) Baseline BWt (g) Final BWt (g) % Change in BWt
Saline 31.1±2.52 33.38±0.42 7.33±0.42
DMH 31.68±0.36 33.94±0.4 7.14±0.52
Oxaliplatin 30.41±0.73 28.78±0.46 −5.25±0.45
Metformin (100 mg/kg) 30.04±0.71 31.98±0.88 6.48±0.23
Metformin (200 mg/kg) 29.84±0.75 31.08±1.37 3.98±0.26
Combination 1 28.26±1.91 30.38±0.64 7.58±0.49
Combination 2 29.82±1.73 32.3±1.02 8.6±0.27
B)
Saline 34.43±0.5 31.86±1.24 −7.45±0.32
DMH 36.43±0.44 31.08±0.67 −14.67±0.63
Oxaliplatin 35.46±0.48 28.64±0.48 −19.24±1.32
Metformin (100 mg/kg) 36.3±2.23 31.66±0.76 −30.66±0.24
Metformin (200 mg/kg) 33.66±2.17 29.46±0.65 −12.78±0.57
Combination 1 35.5±2.16 30.4±1.21 −14.36±1.17
Combination 2 38.3±2.53 30.56±0.92 −20.2±1.64

Mice [except saline group] were injected with 1,2-dimethylhydrazine (DMH) weekly for 15 week to induce colon cancer then treated with oxaliplatin and/or metformin (100 or 200 mg/kg) for 4 weeks. Percent change in BWt was calculated using a formula: % change BWt  =  [(final BWt- baseline BWt)/baseline BWt] x 100. Baseline BWt: was recorded at the end of week 4 and final BWt was recorded at the end of week 24. Results are expressed as mean ± S.E.M and analyzed using two-way ANOVA followed by Tukey's post-hoc test at P<0.05. The mean baseline body weight in experiment I was compared to that recorded in experiment II using unpaired student's t test.