Figure 4. β-secretase doesn't interact with LRP/LR as revealed by FRET analysis.

(A) FRET did not occur between the donor BACE1-GFP and the acceptor LRP-dsRed in HEK293 cells as no signal was detected on the normalized FRET scale. Scale bar: 20 µm. (B) Similarly, a lack of interaction was detected between LRPdsRed and BACE1-GFP when IMR-32 cells were used. Scale bars:10 µm.