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In monocytes, C. trachomatis and C. muridarum trigger inflammasome-mediated caspase-1 activation and IL-1β secretion through K+ efflux and ROS production, through a mechanism involving the Syk kinase. Chlamydial infection induces K+ efflux and ROS production, which promote assembly of the NLRP3 inflammasome through a pathway involving the Syk kinase. The inflammasome in turn activates caspase-1, which processes pro-IL-1β into the mature IL-1β form.
