Table 3. Mean (SE) of dependent variables (DV) of the empathy & social interaction measures and main effects of Treatment Condition and Task Variable* (Valence: MET; Player Type: Social Ball Tossing Game; Risk-Benefit: Trust Game); statistically significant treatment-placebo contrasts are flagged with an ‘a’; ns = not significant, na = not applicable.
| Treatment Condition (Mean ± SE) | GLM | |||||||
| Treatment Condition | Task variable* | |||||||
| Tests/DV | MDMA | Pindolol + MDMA | Oxytocin | Placebo | F | p | F | p |
| RMET | Valence | |||||||
| Total correct (#) | 26.85 (.95) | 26.60 (.87) | 27.85 (.64) | 27.55 (.65) | 1.47 | ns | na | na |
| Correct - (%) | 66.67 (3.47) | 66.67 (3.42) | 72.92 (4.35) | 69.17 (3.20) | 1.65 | ns | 23.39 | <.001 |
| Correct + (%) | 85.62 (3.18) | 84.37 (3.38) | 87.50 (2.56) | 89.37 (2.27) | ||||
| Correct 0 (%) | 75.00 (3.11) | 74.06 (2.91) | 75.62 (2.93) | 75.62 (2.31) | ||||
| RT correct – (msec) | 5587.30 (514.143) | 5212.28 (354.36) | 6371.73 (459.73) | 6010.49 (385.29) | 1.04 | ns | 10.54 | <.001 |
| RT correct + (msec) | 4946.27 (465.87) | 5051.72 (526.56) | 4981.94 (324.10) | 5367.53 (440.58) | ||||
| RT correct 0 (msec) | 5999.79 (444.51) | 5419.69 (406.08) | 6200.52 (433.41) | 6270.49 (460.19) | ||||
| MET | ||||||||
| Cognitive Empathy | Valence | |||||||
| Total correct (#) | 23.90 (.80) | 23.15 (.76) | 23.80 (.91) | 23.90 (.68) | .41 | ns | na | na |
| Correct – (%) | 55.75 (3.19) | 55.00 (2.49) | 57.25 (3.25) | 54.25 (3.00) | .41 | ns | 6.53 | .019 |
| Correct + (%) | 63.75 (2.40) | 60.75 (2.21) | 61.75 (2.57) | 65.25 (1.93) | ||||
| RT correct - | 4329.30 (288.59) | 4075.77 (252.52) | 4768.94 (379.26) | 4521.86 (296.12) | 1.37 | ns | 39.24 | <.001 |
| RT correct + | 3834.17 (344.62) | 3428.98 (241.42) | 4091.71 (351.53) | 3983.39 (238.48) | ||||
| Emotional Empathy (Explicit; ‘Concerned’) | Valence | |||||||
| Rating all items | 4.26 (.27)a | 4.35 (.27)a | 4.18 (.30) | 3.94 (.27) | 2.70 | .054 | na | na |
| Rating - | 4.28 (.41) | 4.29 (.38) | 4.41 (.39) | 4.23 (.37) | 2.70 | .054 | .33 | ns |
| Rating + | 4.23 (.36) | 4.40 (.39) | 3.94 (.32) | 3.66 (.30) | ||||
| Emotional Empathy (Implicit; ‘Aroused’) | Valence | |||||||
| Rating all items | 4.39 (.27)a | 4.44 (.26)a | 4.18 (.30) | 4.02 (.27) | 3.33 | .026 | na | na |
| Rating - | 4.51 (.34) | 4.58 (.34) | 4.42 (.34) | 4.28 (.33) | 3.33 | .026 | 2.01 | ns |
| Rating + | 4.26 (.31) | 4.30 (.31) | 3.94 (.31) | 3.75 (.29) | ||||
| IRI | ||||||||
| PT | 24.10 (.80) | 24.91 (.74) | 25.53 (1.10) | 24.53 (.83) | 1.26 | ns | na | na |
| FS | 22.11 (1.74) | 23.42 (1.56) | 22.37 (1.78) | 22.16 (1.49) | .98 | ns | ||
| EC | 23.41 (1.23) | 26.61 (.69)a | 25.42 (.87)a | 24.26 (.71) | 4.16 | .010 | ||
| PD | 15.63 (.89) | 16.42 (.81)a | 17.37 (.96) | 14.26 (.91) | 4.72 | .005 | ||
| Trust Game | Benefit/Risk | |||||||
| Trust (%) | 56.30 (.06) | 50.80 (.06) | 56.00 (.06) | 52.20 (.06) | 1.65 | ns | B: 7.58 | .013 |
| R: 62.37 | <.001 | |||||||
| Reciprocity (%) | 40.50 (.09) | 38.90 (.09) | 34.70 (.09) | 34.50 (.09) | .47 | ns | B: 2.86 | ns |
| R: 5.16 | .035 | |||||||
| SBTG | Player Type | |||||||
| Tosses-Good (%) | 49.79 (5.21) | 47.77 (4.26) | 48.34 (5.04) | 45.30 (3.73) | 1.00 | ns | 13.24 | <.001 |
| Tosses- Bad (%) | 25.01 (3.41) | 29.15 (3.63) | 30.44 (3.80) | 27.36 (2.93) | ||||
| Tosses-Neutral (%) | 25.00 (3.31) | 23.08 (2.17) | 21.22 (2.28) | 27.30 (2.26) | ||||
| SBTG-questionnaire | ||||||||
| Trust- Good | 4.15 (.47) | 5.12 (.37) | 4.05 (.43) | 4.70 (.44) | 1.04 | ns | na | na |
| Trust-Bad | 3.95 (.39) | 4.05 (.33) | 4.57 (.42) | 4.30 (.40) | ||||
| Trust-Neutral | 4.20 (.47) | 3.15 (.42) | 4.07 (.29) | 3.97 (.40) | ||||
| Preference-Good | 4.15 (.53) | 5.22 (.39) | 4.02 (.51) | 5.00 (.47) | 1.07 | ns | na | na |
| Preference-Bad | 3.95 (.48) | 3.97 (.33) | 4.67 (.47) | 4.10 (.44) | ||||
| Preference-Neutral | 4.05 (.49) | 3.20 (.48) | 4.02 (.33) | 3.97 (.42) | ||||