Table 1. Enrichments for different sets of sequences in the interactor lists for prion, prionogenic and prion-like proteins in budding yeast^*.

Are these sets enriched in the lists of interactors of the sets listed below? →	KP (10/5796 proteins) (152/36467 interactions)	EPD (27/5796 proteins) (314/36467 interactions)	NQP (354/5796 proteins) (4405/36467 interactions)	EPN (18/5796 proteins) (259/36467 interactions)	Disordered proteins (>0.5 disordered) not in NQP data set (251/5796 proteins) (2432/36467 interactions)
KP	1/152 (NS)	5/152 (0.010)†	20/152 (NS)	1/152 (NS)	6/152 (NS)
EPD	5/314 (0.010)†	7/314 (0.019)†	63/314 (0.000034)	7/314 (0.0074)†	9/314 (0.00083, depletion)
EPN	1/259 (NS)	7/259 (0.0074)†	46/259 (0.0050)†	3/259 (NS)	7/259 (0.0013, depletion)†
NQP	20/4405 (NS)	63/4405 (0.000034)	251/4405 (<1e−30, depletion)	46/4405 (0.0047)†	162/4405 (1e−20, depletion)

*The interactor lists are in the rows of the table, and the sets that are tested as enriched/depleted or not, are in the columns. These sets are explained in the main text. At the head of each column is given the total number of proteins of each set type, and the total number of interactions involving them. In each cell, is given the number of interactors that are members of the sets tested as enriching/depleted, expressed as a fraction of the total number of interactors. In brackets is given the hypergeometric probability for this enrichment/depletion, with NS for non-significant (P-value threshold  = 0.05). Values that are significant enrichments after Holm-Bonferroni correction are in bold, significant depletions in italics.

^†These P-values become non-significant after a Holm-Bonferroni correction over all tests performed (totalling 72).