. 2014 Jun 27;9(6):e100615. doi: 10.1371/journal.pone.0100615

Table 2. Enrichments of proteins with and without protein-binding domains (PBDs), in the interactor lists of the EPDs^*.

Are these sets enriched in the interactors of the sets listed below? →	NQPs (4405/36467 interactions)	Proteins containing PBDs but not NQP domains^** (19481/36467 interactions)	Proteins containing NQP domains but not PBDs (2877/36467 interactions)	Proteins containing NQP domains and PBDs (1631/36467 interactions)	Disordered proteins (>0.5 disordered) not in NQP data set (2432/36467 interactions)
EPD	63/314 (0.000034)	89/314 (9e−20,depletion)	48/314 (0.0000079)	15/314 (NS)	9/314 (0.00083, depletion)
EPD hubs	36/78 (8e−14)	8/78 (9e−16,depletion)	27/78 (2e−11)	9/78 (0.006)^†	0/78 (0.005, depletion)^†
EPD non-hubs	27/236 (NS)	81/236 (1e−09,depletion)	21/236 (NS)	6/236 (0.048)^†	9/236 (0.022, depletion)^†

*As for Table 1.

**Proteins containing PBDs are those containing predicted coiled-coil regions or protein-binding domains defined specifically as such, in InterPro (see Methods for details). The enrichment of proteins containing PBDs in the list of their own interactors is very highly significant (P = 4e−52).

^†

As for Table 1.

Table 2. Enrichments of proteins with and without protein-binding domains (PBDs), in the interactor lists of the EPDs*.

Table 2. Enrichments of proteins with and without protein-binding domains (PBDs), in the interactor lists of the EPDs^*.