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. 2014 Jun 27;9(6):e100834. doi: 10.1371/journal.pone.0100834

Figure 1. Increased oxidative stress in Sod1 −/− mice leads to early onset limb muscle atrophy and weakness.

Figure 1

(A) Gastrocnemius and extensor digitorum longus muscle mass expressed as % of body mass from in wild-type (WT, N = 47, 7 months old, white) and Sod1 −/− (N = 32, 7 months old, gray) mice. (B, left) Chart showing the average (10 trials) grip strength in WT (N = 14, 5–6 months old, white) and Sod1 −/− (N = 13, 5 months old, gray) mice. (B, right) Chart showing time to fall in the wire hanging assay for WT (N = 10, 5–6 months old, white) and Sod1 −/− (N = 8, 4–5 months old, gray) mice. All mice are between 4 to 10 months of age. Data are plotted as mean with error bars representing standard error. Statistics: t-test, *p<0.05, **p<0.01.