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. 2014 Jun 27;9(6):e100523. doi: 10.1371/journal.pone.0100523

Figure 8. Proposed mechanism of MLH1 action on FXN transcription.

Figure 8

Images illustrate: (A) inhibition of transcription by triplex DNARNA R-loop formation; (B) binding of MLH1 and MSH6 to the R-loop, together with other unknown factors (?), and (C) release of bound premature mRNA to allow continuation of transcription.