Skip to main content
. Author manuscript; available in PMC: 2015 Jun 17.
Published in final edited form as: Vaccine. 2014 May 6;32(29):3573–3576. doi: 10.1016/j.vaccine.2014.04.086

Figure 1. HKY vaccine significantly prolonged survival in DKA/cortisone acetate-treated mice infected with R. oryzae.

Figure 1

Mice were vaccinated with different doses of HKY. Control mice were given PBS alone. Mice were then treated to produce DKA and dosed with cortisone acetate prior to intratracheal infection with R. oryzae 99-880 isolate at 2.5 × 105 spores. In the first experiment (delivered inoculum = 7.8 × 103 spore per mouse) (A), vaccinating mice (n= 7–9 per arm) with any HKY regimen prolonged survival compared to PBS-vaccinated mice (*P < 0.02). The lower dose of HKY, 6.0 × 107 spores, administered three times also demonstrated better efficacy than a higher dose of 1.2 × 108 HKY administered three (**P = 0.001) or four times. In the second experiment (delivered inoculum = 3.3 × 103 spores) (B), all HKY regimens prolonged survival compared to PBS-vaccinated mice, but only the lower dose regimen of 6.0 × 107 HKY prolonged survival significantly (* P=0.009) (n=8–9 mice per arm).