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. 2014 May 20;77(6):1445–1451. doi: 10.1021/np500198g

Figure 2.

Figure 2

Concentration–response analysis of triterpene acids and mPGES-1 activity. Microsomal preparations of IL-1β-stimulated A549 cells were preincubated with (A) 3-α-hydroxy-8,24-dienetirucallic acid (5), (B) 3α-acetoxy-8,24-dienetirucallic acid (6), (C) 3-α-hydroxy-7,24-dienetirucallic acid (9), and (D) 3α-acetoxy-7,24-dienetirucallic acid (10) at the indicated concentrations for 15 min at 4 °C. The reaction was started by addition of 20 μM PGH2, and after 60 s at 4 °C the reaction was terminated and PGE2 was analyzed Data are given as mean + SEM, n = 4–7.