Table 2. Effects of Triterpene Acids from Gum Resins of Boswellia spp. on COX-1 and COX-2 Activity in a Cell-Free Assay (mean ± SEM, n = 3, 4).
compound | COX-1 residual activity at 10 μM | COX-2 residual activity at 10 μM |
---|---|---|
5 | 81.9 ± 8.3 | n.d.c |
6 | 63.2 ± 4.1 | 81.8 ± 3.1 |
7 | 82.3 ± 1.2 | 83.4 ± 8.6 |
8 | 81.1 ± 6.5 | 70.1 ± 7.0 |
9 | 69.6 ± 3.7 | 83.4 ± 3.7 |
13 | 64.8 ± 9.5 | 66.3 ± 7.6 |
17 | 90.7 ± 7.7 | 75.8 ± 6.4 |
indomethacina | 41.3 ± 5.2 | n.d. |
celecoxibb | n.d. | 22.4 ± 3.8 |
Indomethacin, 10 μM, reference compound for COX-1.
Celecoxib, 5 μM, reference compound for COX-2.
n.d. = not determined.