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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Mar 4;231(14):2799–2809. doi: 10.1007/s00213-014-3452-2

Figure 4. Effects of prenatal (EKyn) and adolescent (AdKyn) kynurenine treatment on tissue levels of kynurenic acid (KYNA) in adulthood.

Figure 4

(A) Treatment with kynurenine (100 mg/day; EKyn) from ED 15 to ED 22 raised KYNA in the hippocampus of adult offspring (PD 56–85). Data are the mean ± SEM (ECon: n = 6 litters; EKyn n = 4 litters). * P < 0.05 vs. control (ECon). (B) Exposure to kynurenine (300 mg/kd/day; AdKyn) from PD 42 to PD 49 did not impact KYNA levels in the hippocampus in adulthood (PD 70–85). Data are the mean ± SEM (n = 8 per group).