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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Ann N Y Acad Sci. 2014 Mar 27;1319(1):1–18. doi: 10.1111/nyas.12393

Fig. 1.

Fig. 1

Topo-ontogenic map of macrophages and their progenitors in steady state. HSCs in bone marrow produce discrete intermediate progenitor populations, which increasingly lose self-renewing capacity as they commit to a given lineage. HSC-derived monocytes are found in circulation and in a splenic reservoir and can renew macrophages upon tissue extravasation. Some tissue macrophages develop in the embryo (yolk sac) before the appearance of HSCs and are maintained independently from the bone marrow.