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. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Nature. 2014 May 21;510(7506):542–546. doi: 10.1038/nature13270

Extended Data Figure 1.

Extended Data Figure 1

Effect of acute galegine treatment and acute AMPK activator treatment in vivo. A 20-minute infusion of galegine in rats (a) decreased fasting plasma glucose concentrations and (b) decreased fasting plasma insulin concentrations (c) increased plasma lactate concentrations, (d) independently of any changes in gluconeogenic gene expression. (e) AMPK was activated by acute galegine treatment. (f) 20-minute infusions of A-769662 in rats activated had no effect on fasting plasma glucose concentrations (g) or endogenous glucose production, in spite of (h) comparable activation of AMPK. Data are mean ± SEM, (saline, n=6; galegine, n=8; A-769662, n=5 biological replicates). * P<0.05, **P<0.01, ***P<0.001 by unpaired t-test.