Table 1.

Associations of high-grade glioma risk with SNPs near TERC, TERT, and RTEL1 in the UCSF and Mayo Clinic Adult Glioma Studies, The Cancer Genome Atlas (TCGA) and The Wellcome Trust Consortium.

SNP	Chr.	Position	Risk Allele	Gene	Study	Number cases / controls	RAF cases / controls	OR (95% CI)	P
rs1920116	3	169579971	G	TERC	Discovery GWAS	1013 / 6595	0.77 / 0.72	1.31 (1.18-1.46)	8.7×10−7
					Replication	631 / 1141	0.76 / 0.71	1.27 (1.09-1.51)	3.4×10−3
					Combined Total	1644 / 7736	0.77 / 0.72	1.30 (1.19-1.42)	8.3×10−9
rs2736100	5	1286516	C	TERT	Discovery GWAS	1013 / 6595	0.60 / 0.51	1.43 (1.30-1.57)	2.9×10−13
					Replication	605 / 1141	0.57 / 0.49	1.29 (1.12-1.49)	5.8×10−4
					Combined Total	1618 / 7736	0.59 / 0.51	1.39 (1.28-1.50)	1.4×10−15
rs6010620	20	62309839	G	RTEL1	Discovery GWAS	1013 / 6595	0.84 / 0.76	1.53 (1.36-1.72)	7.0×10−13
					Replication	631 / 1141	0.83 / 0.75	1.64 (1.37-1.97)	1.4×10−7
					Combined Total	1644 / 7736	0.84 / 0.76	1.56 (1.42-1.72)	4.7×10−19

RAF: risk allele frequency