Table 3.

Regressions of language performance with gray matter atrophy in amyotrophic lateral sclerosis and Parkinson’s disease

Anatomic locus (Brodmann area)	MNI coordinates			Z score	Cluster size (voxels)
	x	y	z
Gray matter atrophy
ALS < control
L middle frontal gyrus (9)	−32	12	34	3.19	145
L precentral gyrus (6)*	−46	0	44	N/A	N/A
L cingulate gyrus (32)	−10	46	10	4.46	226
L middle frontal gyrus (10)	−26	52	4	3.30	307
L fusiform gyrus (20)	−42	−28	−24	3.23	135
L fusiform gyrus (37)	−26	−42	−18	3.98	160
R cingulate gyrus (32)	20	4	48	3.45	164
R medial frontal gyrus (10)	2	42	−8	3.18	558
R middle frontal gyrus (10)	24	56	4	4.62	376
R middle temporal gyrus (39)	50	−74	20	3.30	241
PD < control
L fusiform gyrus (20)	−42	−28	−22	5.09	22,854
L cingulate gyrus (23)	−6	−42	22	3.48	521
L superior frontal gyrus (6)	−24	−8	72	3.13	109
R precuneus (31)	12	−60	12	3.93	384
R superior frontal gyrus (6)	18	2	68	3.90	1,421
Regression of action verb accuracy with gray matter atrophy
ALS
L precentral gyrus (6)	−44	2	46	4.20	131
L cingulate gyrus (24)	−10	40	8	3.79	100
R middle frontal gyrus (10)	30	50	14	3.95	198

^*cluster subpeak in this location