Fig. 1.

Transcriptome changes during human preimplantation development. (A) Principal component analysis showing that samples at the same stage of development cluster closer together than they do to any other sample. (B) Hierarchical sample classifications of normalized transcriptional profiling of differentially expressed genes. (C) GenePattern K-means analysis identifies ten clusters (1 to 10) of transcripts that change their expression between the MII oocyte and the 10-cell stage. ESC, embryonic stem cell.