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Summary diagram of the hypoxia–Sp1–miR-34c-5p signaling that regulates sGCβ1 subunit expression. Hypoxia upregulates Sp1 expression. Sp1 in turn transcriptionally promotes miR-34c-5p expression by direct interaction with the promoter of miR-34c-5p in the nucleus. After transport into the cytosol, miR-34c-5p exerts a translational blockade of sGCβ1 subunit by binding in the 3′-UTR and then decreases sGC activity. sGC, soluble guanylyl cyclase; RISC, RNA-induced silencing complex.
