Table 1.

Biological functions associated with differentially methylated genes in XX vs. XX + T mice determined by IPA

Category	Function annotation	Striatum		BNST/POA
		p value	Number of genes	p value	Number of genes
Nervous system development and function	Morphology of nervous system	1.02E − 08	108	3.91E − 06	63
	Development of central nervous system	6.63E − 08	80	4.71E − 08	54
	Morphology of nervous tissue	7.88E − 06	72	7.75E − 05	44
	Neuritogenesis	1.05E − 05	48	1.03E − 07	37
	Outgrowth of neurites	4.68E − 05	39	2.19E − 03	22
	Coordination	4.69E − 05	31	1.67E − 02	15
	Axonogenesis	1.48E − 04	24	1.18E − 04	17
	Excitatory postsynaptic potential	1.51E − 04	18	5.55E − 03	10
	Growth of neurites	1.75E − 04	41	5.21E − 03	23
	Morphology of neurites	7.77E − 04	23	1.99E − 04	17
	Morphology of dendritic spines	7.78E − 04	5	7.85E − 04	4
	Guidance of axons	9.29E − 04	21	1.60E − 05	18
	Outgrowth of axons	9.56E − 04	14	9.82E − 03	8
	Neurotransmission	6.32E − 05	44	-	-
	NMDA-mediated synaptic current	2.93E − 04	6	-	-
	Action potential of cells	3.58E − 04	18	-	-
	Long-term depression	1.30E − 03	13	-	-
	Quantity of neurons	-	-	3.81E − 05	24
	Cell viability of neurons	-	-	1.93E − 02	12
Cellular assembly and organization	Organization of cytoskeleton	1.86E − 07	125	1.72E − 06	77
	Microtubule dynamics	2.17E − 07	108	7.64E − 06	65
Skeletal and muscular system development and function	Development of muscle	2.55E − 06	49	-	-
Cell death and survival	Apoptosis	7.68E − 06	250	1.70E − 03	138
Cellular growth and proliferation	Proliferation of neuronal cells	-	-	1.25E − 02	13
Behavior	Learning	3.33E − 03	38	2.81E − 04	27
	Social behavior	-	-	2.59E − 03	7

This table shows examples of functional categories enriched in the XX vs. XX + T comparison for both the striatum and BNST/POA.