Table 2.
Examples of top ‘neurological disease’ functional categories that were significantly enriched in striatal testosterone-influenced genes
| Function annotation | p value | Number of genes |
|---|---|---|
| Movement disorder |
1.03E − 04 |
118 |
| Congenital anomaly of brain |
6.81E − 04 |
26 |
| Dyskinesia |
3.36E − 03 |
73 |
| Huntington's disease |
3.43E − 03 |
70 |
| Hyperactive behavior |
3.47E − 03 |
18 |
| Schizophrenia |
3.90E − 03 |
56 |
| Jervell and Lange-Nielsen syndrome |
4.66E − 03 |
2 |
| Seizures |
5.08E − 03 |
33 |
| Mood disorder |
5.35E − 03 |
50 |
| Hydrocephalus |
6.76E − 03 |
11 |
| Ataxia |
6.89E − 03 |
22 |
| Amyotrophic lateral sclerosis |
7.00E − 03 |
18 |
| Incoordination |
9.03E − 03 |
3 |
| Oligodendroglioma |
9.64E − 03 |
5 |
| Spina bifida |
1.33E − 02 |
7 |
| Degeneration of brain | 1.34E − 02 | 8 |
Examples of top ‘neurological disease’ functional categories that were significantly enriched in the list of testosterone-influenced genes (XX vs. XX + T) in the striatum as determined by Ingenuity Pathway Analysis.