Table 3.
Testosterone-driven methylation changes at several genes are maintained into adulthood
| Gene symbol | Δ Me at PN4 | Fragment coordinate at PN4 | Δ Me at PN60 | Fragment coordinate at PN60 |
Associated genomic features |
||
|---|---|---|---|---|---|---|---|
| Prom | GB | CGI | |||||
| Striatum |
|
|
|
|
|
|
|
| 4921515J06Rik |
0.22 |
chr3:108742959-108743236 |
−0.13 |
chr3:108742959-108743236 |
X |
X |
X |
| Taf4b |
−0.11 |
chr18:15048075-15048318 |
−0.1 |
chr18:15048075-15048318 |
|
X |
|
| F8a |
−0.1 |
chrX:70473904-70474128 |
−0.13 |
chrX:70474305-70474419 |
|
X |
X |
| Fmr1 |
−0.1 |
chrX:65932427-65932537 |
−0.11 |
chrX:65932427-65932537 |
|
X |
X |
| Kcnq1 |
0.28 |
chr7:150455734-150456023 |
−0.14 |
chr7:150481372-150481523 |
|
X |
X |
| Rbbp7 |
−0.23 |
chrX:159198854-159199070 |
−0.12 |
chrX:159198688-159198839 |
X |
X |
X |
| Sox3 |
−0.11 |
chrX:58145676-58145842 |
−0.11 |
chrX:58146499-58146619 |
X |
X |
X |
| Dab1 |
−0.1 |
chr4:104298501-104298709 |
−0.11 |
chr4:104275571-104275789 |
|
X |
|
| Nnat |
−0.13 |
chr2:157385832-157386011 |
−0.12 |
chr2:157386045-157386214 |
X |
X |
X |
| Arid3b |
−0.19 |
chr9:57685767-57685957 |
−0.11 |
chr9:57685767-57685957 |
X |
|
|
| Grip1 |
−0.21 |
chr10:119402892-119403155 |
−0.12 |
chr10:119402892-119403155 |
|
X |
X |
| Lonrf3 |
−0.1 |
chrX:33868422-33868652 |
−0.12 |
chrX:33869078-33869231 |
X |
X |
X |
| Clybl |
−0.15 |
chr14:122662639-122662815 |
−0.12 |
chr14:122629995-122630146 |
|
X |
|
| Sorcs2 |
−0.13 |
chr5:36720053-36720329 |
−0.12 |
chr5:36511861-36512058 |
|
X |
|
| 2610018G03Rik |
−0.11 |
chrX:48194982-48195124 |
−0.12 |
chrX:48194982-48195124 |
|
X |
X |
| Rap2c |
−0.17 |
chrX:48370998-48371218 |
−0.12 |
chrX:48370998-48371218 |
X |
X |
X |
| Fndc3b |
0.12 |
chr3:27382887-27383015 |
−0.21 |
chr3:27368716-27368995 |
|
X |
|
| Ubash3b |
−0.12 |
chr9:40872064-40872268 |
−0.14 |
chr9:40872064-40872268 |
|
X |
|
| Foxk1 |
−0.25 |
chr5:142921051-142921281 |
−0.27 |
chr5:142921051-142921281 |
|
X |
|
| BNST/POA |
|
|
|
|
|
|
|
| Igfbp7 |
−0.13 |
chr5:77809526-77809779 |
−0.21 |
chr5:77786342-77786589 |
|
X |
|
| Odz3 |
−0.11 |
chr8:49626485-49626755 |
0.12 |
chr8:49395012-49395267 |
|
X |
|
| Emd |
−0.13 |
chrX:71500275-71500386 |
−0.11 |
chrX:71500067-71500242 |
X |
X |
X |
| Herc3 |
−0.12 |
chr6:58856760-58856872 |
−0.12 |
chr6:58856760-58856872 |
X |
X |
X |
| Commd1 |
−0.16 |
chr11:22873668-22873935 |
−0.12 |
chr11:22872579-22872758 |
X |
X |
X |
| Bcor |
−0.14 |
chrX:11715730-11715985 |
−0.11 |
chrX:11703662-11703859 |
|
X |
|
| Nap1l5 |
−0.12 |
chr6:58856760-58856872 |
−0.12 |
chr6:58856760-58856872 |
X |
X |
X |
| Gpr179 |
−0.14 |
chr11:97193837-97194108 |
−0.11 |
chr11:97197795-97197992 |
|
X |
|
| Zrsr1 |
−0.16 |
chr11:22873668-22873935 |
−0.12 |
chr11:22872579-22872758 |
X |
X |
X |
| Lonrf3 |
−0.12 |
chrX:33868422-33868652 |
−0.1 |
chrX:33869078-33869231 |
X |
X |
X |
| Sdk1 | −0.13 | chr5:142590169-142590448 | 0.12 | chr5:142312410-142312648 | X | ||
Differential CpG methylation values between XX and XX + T at PN4 and PN60 are shown. Negative delta methylation indicates higher methylation in XX + T. Genomic features associated with the differentially methylated region are indicated by the last three columns. An ‘X’ indicates that the fragment overlaps with a feature (Prom promoter, GB gene body, CGI CpG island).