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. Author manuscript; available in PMC: 2014 Jun 28.
Published in final edited form as: Neurobiol Aging. 2011 Aug 19;33(4):830.e1–830.12. doi: 10.1016/j.neurobiolaging.2011.07.005

Figure 2. 3xTgAD mice exhibit an anxiety phenotype that is exacerbated by mild chronic social stress.

Figure 2

The distance traveled in the open field, a test of anxiety. Less distance traveled corresponds to greater anxiety. Results are expressed as distance traveled in zone 1 (the center area), the residual (area nearest the perimeter of the apparatus) and total distance traveled for wild type and AD mice. Basal anxiety was higher in AD mice compared to WT mice. After 6 weeks of social stress, AD mice displayed heightened anxiety compared to non-stressed controls whereas WT mice did not.