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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Hum Mutat. 2014 Feb 11;35(6):738–755. doi: 10.1002/humu.22506

Figure 5.

Figure 5

The functions and locations of TP53 are modulated by methylation of lysines at its C terminus and the interactions of these with methyl-binding proteins in basal conditions and after DNA damage. TP53 is mono- or dimethylated at four lysines under basal conditions (Lys370Me1, Lys373Me2, L:ys382Me1) or after DNA damage (Lys370Me2, Lys362Me1, Lys382Me2) by at least six lysine methyltransferases (see text). These lysines as well as others and nearby serines and threonines also are subject to PTMs including ubiquitylation, neddylation (not shown), sumoylation (not shown), and phosphorylation. The choreography of these events is not well known.