Table 2.
Comparison of Pre- and Peritransplant Factors Between Patients With Hypoalbuminemia and Those With Normal Albumin
| Hypoalbuminemia (n=208) | Normal Albumin (n=614) | P Value | |
|---|---|---|---|
| Clinical characteristics at the time of transplant | |||
| Age, y | 54.2±11.5 | 52.6±12.5 | 0.097 |
| Sex (men, %) | 156 (75.0%) | 481 (78.3%) | 0.319 |
| Race (black, %) | 40 (19.2%) | 100 (16.3%) | 0.329 |
| BMI, kg/m2 | 23.1±4.7 | 27.1±4.5 | <0.0001 |
| Primary disease (ischemic, %) | 101 (48.6%) | 266 (43.3%) | 0.189 |
| UNOS status (1A, %) | 117 (56.3%) | 200 (32.6%) | <0.0001 |
| LVAD requirement, % | 95 (45.7%) | 173 (28.2%) | <0.0001 |
| CMV serology (positive, %) | 130 (63.7%) | 366 (61.0%) | 0.489 |
| Perioperative and donor-related information | |||
| Albumin, mg/dL | 3.1±0.4 | 4.2±0.4 | <0.0001 |
| Sodium, mEq/L | 130.0±6.1 | 140.1±5.7 | <0.0001 |
| Potassium, mEq/L | 4.3±0.5 | 4.3±0.5 | 0.792 |
| BUN, mg/dL | 27.3±16.3 | 30.0±15.4 | 0.031 |
| Cre, mg/dL (n=820) | 1.3±0.8 | 1.4±0.7 (n=612) | 0.234 |
| Total bilirubin, mg/dL | 1.4±1.5 | 1.1±0.8 | 0.009 |
| Direct bilirubin, mg/dL | 0.5±0.7 | 0.3±0.4 | <0.0001 |
| AST, IU/L | 40.7±96.1 | 32.8±33.9 | 0.082 |
| ALT, IU/L | 39.3±85.5 | 30.3±35.1 | 0.033 |
| Total cholesterol, mg/dL (n=814) | 133.4±48.5 | 149.9±47.1 (n=606) | <0.0001 |
| Triglyceride, mg/dL (n=820) | 114.2±57.1 | 127.5±66.6 (n=612) | 0.010 |
| Hematocrit, % | 32.6±5.4 | 37.5±5.5 | <0.0001 |
| Perioperative and donor-related information | |||
| Ischemic time, min (n=503) | 183.3±56.7 (n=122) | 195.9±56.4 (n=381) | 0.032 |
| Donor age, y | 35.6±13.7 | 33.7±13.2 | 0.080 |
| Donor sex (men, %) | 114 (58.2%) | 339 (58.2%) | 0.997 |
| CMV serology (D+/R−, %), n=807 | 41 (20.3%; n=202) | 137 (22.6%; n=605) | 0.486 |
| HLA mismatch (≥5, %), n=763 | 66 (34.2%; n=193) | 161 (28.3%; n=570) | 0.118 |
ALT indicates alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; BUN, blood urea nitrogen; CMV, cytomegalovirus; D+/R−, serology-positive donor to serology-negative recipients; HLA, histocompatibility locus antigen; LVAD, left ventricular assist device; and UNOS, United Network for Organ Sharing.